Born in Yerevan, Armenia, Sergey Khachatryan won First Prize at the VIII International Jean Sibelius Competition in Helsinki in 2000, becoming the youngest ever winner in the history of the competition. In 2005 he claimed First Prize at the Queen Elisabeth Competition in Brussels.

In 2024/25 season, Sergey’s international presence is sustained by performances with the Orchestra Sinfonica Nazionale della RAI (Cristian Măcelaru), the Lyon National Orchestra (Nikolaj Znaider), the Accademia Nazionale di Santa Cecilia (Myung-Whun Chung), the Montréal Symphony Orchestra (Rafael Payare), the Frankfurter Museumsorchester (Michael Sanderling), the Orquesta de Valencia (Alexander Liebrich), the Toronto Symphony Orchestra (Tarmo Peltokoski), the Gävle Symfoniorkester (Case Scaglione) and a Spanish tour with the Bilbao Symphony Orchestra (Joana Carneiro).

His recent appearances in the United States include with the Seattle Symphony (Ludovic Morlot), the Cleveland Orchestra (Jakub Hrůša) and the National Symphony Orchestra Washington (Vasily Petrenko). He has also performed with the New York Philharmonic, the Boston Symphony, the Philadelphia Orchestra, and the San Francisco Symphony as well as the Ravinia, Aspen, Blossom and Mostly Mozart Festivals. The most recent North American Tour with the Armenian National Philharmonic included such destinations as Roy Thomson Hall in Toronto, Maison Symphonique in Montreal, and Carnegie Hall in New York.

Sergey regularly performs as a duo with his sister, pianist Lusine Khachatryan. Together, they have given recitals at the Wigmore Hall (London), Théâtre des Champs-Élysées and Cité de la Musique (Paris), Amsterdam Concertgebouw, Palais des Beaux Arts (Brussels), Victoria Hall (Geneva), Brucknerhaus Linz, Konzerthaus Dortmund, Auditori Nacional (Madrid), Philharmonie Luxembourg, Carnegie Hall and Alice Tully Hall (New York), and Herbst Theater (San Francisco). 
Sergey and Lusine’s most recent album My Armenia released by Naïve Records, dedicated to the 100th commemoration of the Armenian genocide, has been awarded the Echo Klassik for Chamber Music Recording (20th/21st Century). Together, they have also recorded Brahms Three Sonatas for Violin and Piano. Sergey’s discography on Naïve Records also includes the Sibelius and Khachaturian concerti with Sinfonia Varsovia and Emmanuel Krivine, both Shostakovich concerti with the Orchestre National de France and Kurt Masur, a recording of the Shostakovich and Franck sonatas for violin and piano and the complete sonatas and partitas for solo violin by J. S. Bach.

His latest recording Ysaÿe Sonatas Op. 27 for Naïve Records was released in March 2024 and is the winner of the Preis der deutschen Schallplattenkritik (Chamber Music): in this album he presents the first recording of Ysaÿe’s 6 Solo Sonatas performed on the composer’s Guarneri del Gesù violin.

Highlights of the previous seasons include Sergey’s residency with the Orquesta de Valencia, comprising of several concerts conducted by Alexander Liebreich including a chamber project, Sergey’s residency at the BOZAR in Brussels which comprised of a pair of recitals and a concert with the Orchestre National de Belgique and Hugo Wolff. Re-invitations included the Finnish Radio Symphony Orchestra, the Accademia Nazionale di Santa Cecilia, the Rotterdam and Antwerp Symphony Orchestras, and the Cleveland Orchestra. Sergey also embarked on a tour of the US and Europe with Alisa Weilierstein and Inon Barnatan with a programme entitled “Transfigured Nights” featuring the music of Beethoven, Schoenberg and Shostakovich. Other recent projects included a tour of Japan with the Nippon Foundation and in 2015 Sergey performed Beethoven’s Violin Concerto at the Lucerne Festival with the Wiener Philharmoniker and Gustavo Dudamel as the recipient of the Credit Suisse Young Artist Award.